The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure

Food Chem Toxicol. 2008 Jul;46 Suppl 7:S40-6. doi: 10.1016/j.fct.2008.04.040. Epub 2008 May 16.


Rebaudioside A and stevioside are steviol glycosides extracted from the plant Stevia rebaudiana Bertoni and are used in several countries as food and beverage sweeteners. This randomized, double-blind trial evaluated the hemodynamic effects of 4weeks consumption of 1000mg/day rebaudioside A vs. placebo in 100 individuals with normal and low-normal systolic blood pressure (SBP) and diastolic blood pressure (DBP). Subjects were predominantly female (76%, rebaudioside A and 82%, placebo) with a mean age of approximately 41 (range 18-73) years. At baseline, mean resting, seated SBP/DBP was 110.0/70.3mmHg and 110.7/71.2mmHg for the rebaudioside A and placebo groups, respectively. Compared with placebo, rebaudioside A did not significantly alter resting, seated SBP, DBP, mean arterial pressure (MAP), heart rate (HR) or 24-h ambulatory blood pressures responses. These results indicate that consumption of as much as 1000mg/day of rebaudioside A produced no clinically important changes in blood pressure in healthy adults with normal and low-normal blood pressure.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Pressure / drug effects*
  • Blood Pressure Monitoring, Ambulatory
  • Body Weight
  • Diet
  • Diterpenes, Kaurane / administration & dosage
  • Diterpenes, Kaurane / adverse effects*
  • Double-Blind Method
  • Exercise
  • Female
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Placebos
  • Posture
  • Sweetening Agents / administration & dosage
  • Sweetening Agents / adverse effects*


  • Diterpenes, Kaurane
  • Placebos
  • Sweetening Agents
  • rebaudioside A