Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus

Food Chem Toxicol. 2008 Jul;46 Suppl 7:S47-53. doi: 10.1016/j.fct.2008.05.007. Epub 2008 May 16.


This trial evaluated the effects of 16 weeks of consumption of 1000mg rebaudioside A (n=60) a steviol glycoside with potential use as a sweetener, compared to placebo (n=62) in men and women (33-75 years of age) with type 2 diabetes mellitus. Mean+/-standard error changes in glycosylated hemoglobin levels did not differ significantly between the rebaudioside A (0.11+/-0.06%) and placebo (0.09+/-0.05%; p=0.355) groups. Changes from baseline for rebaudioside A and placebo, respectively, in fasting glucose (7.5+/-3.7mg/dL and 11.2+/-4.5mg/dL), insulin (1.0+/-0.64microU/mL and 3.3+/-1.5microU/mL), and C-peptide (0.13+/-0.09ng/mL and 0.42+/-0.14ng/mL) did not differ significantly (p>0.05 for all). Assessments of changes in blood pressure, body weight, and fasting lipids indicated no differences by treatment. Rebaudioside A was well-tolerated, and records of hypoglycemic episodes showed no excess vs. placebo. These results suggest that chronic use of 1000mg rebaudioside A does not alter glucose homeostasis or blood pressure in individuals with type 2 diabetes mellitus.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / analysis
  • Blood Pressure / drug effects
  • C-Peptide / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diterpenes, Kaurane / administration & dosage*
  • Diterpenes, Kaurane / adverse effects
  • Double-Blind Method
  • Fasting
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Hypoglycemia / epidemiology
  • Lipids / blood
  • Male
  • Middle Aged
  • Placebos
  • Sweetening Agents / administration & dosage*
  • Sweetening Agents / adverse effects


  • Blood Glucose
  • C-Peptide
  • Diterpenes, Kaurane
  • Glycated Hemoglobin A
  • Lipids
  • Placebos
  • Sweetening Agents
  • rebaudioside A