Structural specificity in coiled-coil interactions

Curr Opin Struct Biol. 2008 Aug;18(4):477-83. doi: 10.1016/ Epub 2008 Jun 12.


Coiled coils have a rich history in the field of protein design and engineering. Novel structures, such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area. Scoring methods based on sequence and/or structure can predict interaction preferences in coiled-coil-mediated bZIP transcription factor dimerization. Experimental and computational methods for dealing with the near-degeneracy of many coiled-coil structures appear promising for future design applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Proteins / chemistry*


  • Proteins