Abstract
4-O-Thiocarbamoylmethyl-Neu5Ac2en 3 has strong inhibitory activity toward human parainfluenza virus type 1 (hPIV-1) sialidase compared with the parent Neu5Ac2en 2. We synthesized analogs having thiocarbamoylethyl- 4 and thiocarbamoylpropyl group 5 at the C-4 position of 2. The inhibition degrees of 4 and 5 were weaker than that of thiocarbamoylmethyl analog 3, indicating a remarkable effect of the carbon chain length in thiocarbamoylalkyl groups at the C-4 position on inhibitory activities against hPIV-1 sialidase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Humans
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N-Acetylneuraminic Acid / analogs & derivatives*
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N-Acetylneuraminic Acid / chemistry
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N-Acetylneuraminic Acid / pharmacology
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Neuraminidase / antagonists & inhibitors*
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Parainfluenza Virus 1, Human / drug effects*
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Structure-Activity Relationship
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Thiocarbamates
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Thiocarbamates
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2-deoxy-2,3-dehydro-N-acetylneuraminic acid
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Neuraminidase
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N-Acetylneuraminic Acid