Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects

Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):1-8. doi: 10.1016/j.prostaglandins.2008.04.002. Epub 2008 May 2.


Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPCs (ox-GPC) are potent agonists for the platelet-activating factor receptor and peroxisome proliferator-activated receptor gamma. This review discusses these new biologically active lipids and their down-stream receptor targets that provide a unique system of biosensors for detecting and responding to UVR photo-oxidation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Keratinocytes / metabolism
  • Oxidation-Reduction / radiation effects
  • Peroxisome Proliferator-Activated Receptors / metabolism
  • Phosphatidylcholines / metabolism*
  • Phosphatidylcholines / therapeutic use
  • Platelet Activating Factor / metabolism
  • Ultraviolet Rays*


  • Peroxisome Proliferator-Activated Receptors
  • Phosphatidylcholines
  • Platelet Activating Factor