The cystatins: protein inhibitors of cysteine proteinases

FEBS Lett. 1991 Jul 22;285(2):213-9. doi: 10.1016/0014-5793(91)80804-c.


The last decade has witnessed enormous progress of protein inhibitors of cysteine proteinases concerning their structures, functions and evolutionary relationships. Although they differ in their molecular properties and biological distribution, they are structurally related proteins. All three inhibitory families, the stefins, the cystatins and the kininogens, are members of the same superfamily. Recently determined crystal structures of chicken cystatin and human stefin B established a new mechanism of interaction between cysteine proteinases and their inhibitors which is fundamentally different from the standard mechanism for serine proteinases and their inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Cystatin B
  • Cystatins / chemistry*
  • Cystatins / metabolism
  • Cysteine Proteinase Inhibitors*
  • Kininogens / chemistry
  • Kininogens / metabolism
  • Macromolecular Substances
  • Molecular Sequence Data
  • Protein Conformation


  • CSTB protein, human
  • Cystatins
  • Cysteine Proteinase Inhibitors
  • Kininogens
  • Macromolecular Substances
  • Cystatin B