The role of calmodulin kinase II in myocardial physiology and disease

Physiology (Bethesda). 2008 Jun;23:151-9. doi: 10.1152/physiol.00043.2007.


The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca(2+) homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca(2+) homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
  • Heart Diseases / enzymology*
  • Humans
  • Isoenzymes / metabolism
  • Molecular Sequence Data
  • Myocardium / enzymology*
  • Signal Transduction / physiology


  • Isoenzymes
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2