Protective effects of melatonin on oxidative-antioxidative balance and cataract formation in rats

Ann Ophthalmol (Skokie). 2008 Spring;40(1):22-7.

Abstract

We investigated the effects of melatonin on cataract formation in rats exposed to selenite. We concluded that the imbalance between oxidants and antioxidants plays an important role in cataract formation and melatonin decreases cataract incidence in rats by increasing antioxidant activity.

MeSH terms

  • Animals
  • Animals, Newborn
  • Antioxidants / therapeutic use*
  • Aryldialkylphosphatase / metabolism
  • Carboxylic Ester Hydrolases / metabolism
  • Catalase / metabolism
  • Cataract / chemically induced
  • Cataract / enzymology
  • Cataract / prevention & control*
  • Male
  • Melatonin / therapeutic use*
  • Oxidation-Reduction
  • Oxidative Stress
  • Rats
  • Rats, Wistar
  • Sodium Selenite

Substances

  • Antioxidants
  • Catalase
  • Carboxylic Ester Hydrolases
  • arylesterase
  • Aryldialkylphosphatase
  • Sodium Selenite
  • Melatonin