Mechanistic studies of sodium pump

Arch Biochem Biophys. 2008 Aug 1;476(1):12-21. doi: 10.1016/ Epub 2008 Jun 17.


Sodium pump was the first ion pump discovered. A member of the family of active transporters that catalyze adenosine 5'-triphosphate hydrolysis by forming a phosphorylated enzyme intermediate, sodium pump couples the energy released to unequal countertransport of sodium and potassium ions. The ion gradient generated by the pump is important for a variety of secondary physiological processes ranging from metabolite transport to electrical excitation of nerve and muscle. Selected experiments relating structure to function are reviewed.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Animals
  • Cell Membrane / metabolism
  • Ion Transport
  • Models, Molecular
  • Potassium / metabolism*
  • Protein Conformation
  • Sodium / metabolism*
  • Sodium-Potassium-Exchanging ATPase / chemistry
  • Sodium-Potassium-Exchanging ATPase / physiology*


  • Adenosine Triphosphate
  • Sodium
  • Sodium-Potassium-Exchanging ATPase
  • Potassium