Mechanistic Insights Into Glycosidase Chemistry

Curr Opin Chem Biol. 2008 Oct;12(5):539-55. doi: 10.1016/j.cbpa.2008.05.010.


The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocatalysis
  • Enzyme Inhibitors / chemistry
  • Glycoside Hydrolases / chemistry*
  • Glycoside Hydrolases / metabolism*
  • Glycosides / metabolism
  • Humans
  • Protein Conformation
  • Substrate Specificity


  • Enzyme Inhibitors
  • Glycosides
  • Glycoside Hydrolases