Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)

J Pediatr Surg. 2008 Jun;43(6):1191-5. doi: 10.1016/j.jpedsurg.2008.01.005.

Abstract

Total parenteral nutrition is an important adjunct in the care of neonates with surgical disorders. Cholestasis is at present the most worrisome complication of this technique; it is difficult to treat and may progress to eventual cirrhosis and liver failure. This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.

Publication types

  • Case Reports

MeSH terms

  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholecystectomy / methods
  • Cholestasis / etiology
  • Cholestasis / physiopathology
  • Cholestasis / therapy
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Fish Oils / administration & dosage*
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Intestinal Volvulus / diagnosis
  • Intestinal Volvulus / surgery
  • Liver Diseases / etiology*
  • Liver Diseases / physiopathology
  • Liver Diseases / therapy*
  • Liver Function Tests
  • Male
  • Parenteral Nutrition, Total / adverse effects*
  • Parenteral Nutrition, Total / methods
  • Postoperative Complications / diagnosis
  • Reoperation
  • Severity of Illness Index
  • Short Bowel Syndrome / diagnosis
  • Short Bowel Syndrome / etiology
  • Short Bowel Syndrome / therapy*
  • Term Birth
  • Treatment Outcome

Substances

  • Fish Oils