Hydrochalarones: a novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast

J Med Chem. 2008 Jul 10;51(13):3681-3. doi: 10.1021/jm800521j. Epub 2008 Jun 18.

Abstract

Targeted imaging requires contrast agents that remain in the vasculature for extended periods of time. A new contrast agent is described in which gadolinium is encapsulated within an extremely stable carbon sphere, thus allowing for safe extended residence. Water solubility and small particle size is achieved with novel fullerene chemistry, attaching multiple oligoethylene glycol groups through nitrogen chemistry. These new compounds can be used to visualize tissue architecture in vivo with standard MRI techniques.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemistry*
  • Contrast Media / pharmacology*
  • Fullerenes / chemistry*
  • Fullerenes / pharmacology*
  • Gadolinium / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
  • Organ Specificity / drug effects

Substances

  • Contrast Media
  • Fullerenes
  • Gadolinium