Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 31, 295-315

Retinal Axon Growth at the Optic Chiasm: To Cross or Not to Cross


Retinal Axon Growth at the Optic Chiasm: To Cross or Not to Cross

Timothy J Petros et al. Annu Rev Neurosci.


At the optic chiasm, retinal ganglion cell axons from each eye converge and segregate into crossed and uncrossed projections, a pattern critical for binocular vision. Here, we review recent findings on optic chiasm development, highlighting the specific transcription factors and guidance cues that implement retinal axon divergence into crossed and uncrossed pathways. Although mechanisms underlying the formation of the uncrossed projection have been identified, the means by which retinal axons are guided across the midline are still unclear. In addition to directives provided by transcription factors and receptors in the retina, gene expression in the ventral diencephalon influences chiasm formation. Throughout this review, we compare guidance mechanisms at the optic chiasm with those in other midline models and highlight unanswered questions both for retinal axon growth and axon guidance in general.

Similar articles

See all similar articles

Cited by 59 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms


LinkOut - more resources