Structure and dynamic regulation of Src-family kinases

Cell Mol Life Sci. 2008 Oct;65(19):3058-73. doi: 10.1007/s00018-008-8122-2.


Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that reveal conformationally distinct active states within this unique kinase family.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Enzyme Activation
  • Humans
  • Models, Molecular
  • Protein Structure, Tertiary
  • src Homology Domains
  • src-Family Kinases / chemistry*
  • src-Family Kinases / genetics
  • src-Family Kinases / metabolism*


  • src-Family Kinases