Local hospital perspective on a nationwide outbreak of Pseudomonas aeruginosa infection in Norway

Infect Control Hosp Epidemiol. 2008 Jul;29(7):635-41. doi: 10.1086/589332.


Objective: To implement a system for monitoring of rare events based on statistical process control charts.

Design: Statistical process control plotting by g chart of clinical microbiology laboratory data.

Setting: Primary and secondary care Norwegian hospital with a 9-bed intensive care unit.

Results: During the winter of 2001-2002 in Norway, there was a national monoclonal nosocomial outbreak of Pseudomonas aeruginosa infection mainly affecting patients in intensive care units. In the present work, we demonstrate how the use of SPC at one of the affected hospitals would have detected this outbreak several weeks before the alert from the Norwegian National Public Health Institute (NIPH). By plotting the monthly incidence rate of P. aeruginosa infection (with a c chart), we found that the hospital would have been alerted in February; by plotting the number of days between events (with a g chart), we found that the hospital would have detected a process already out of control in early January 2002. Not until 9 weeks later (ie, mid-March) did the NIPH declare the P. aeruginosa outbreak to be national, and a commercially produced mouth swab contaminated during the manufacturing process was found to be the source.

Conclusion: The plotting of rare events, such as an outbreak of nosocomial infection, with a g chart may be used for early detection of a process out of control.

Publication types

  • Evaluation Study

MeSH terms

  • Cross Infection / diagnosis
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Data Interpretation, Statistical
  • Disease Outbreaks*
  • Hospitals / statistics & numerical data*
  • Humans
  • Incidence
  • Laboratories / statistics & numerical data*
  • Microbiology
  • Norway / epidemiology
  • Population Surveillance / methods
  • Pseudomonas Infections / diagnosis
  • Pseudomonas Infections / epidemiology*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / isolation & purification*
  • Quality Assurance, Health Care / methods