Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people

J Gastroenterol Hepatol. 2008 Jun;23(6):914-21. doi: 10.1111/j.1440-1746.2008.05344.x.

Abstract

Background and aim: Hypoadiponectinemia and high tumor necrosis factor-alpha (TNF-alpha) levels are associated with the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the genetic polymorphisms of adiponectin and TNF-alpha in Chinese NAFLD patients and their association with disease severity.

Methods: Seventy-nine patients with histology-proven NAFLD (61 with simple steatosis and 18 with stage 2-4 fibrosis) and 40 controls were tested for the nucleotide polymorphisms at adiponectin -11 391, -11 377, +45, and +276 and TNF-alpha promoters -863, -308, and -238.

Results: There was no significant deviation in the adiponectin and TNF-alpha gene polymorphisms between NAFLD patients and controls, or between patients with simple steatosis and those with stage 2-4 fibrosis. NAFLD patients with -11377G and +45G at the adiponectin gene were more likely to have hypertriglyceridemia. On multivariate analysis, older age, higher body mass index, and higher fasting glucose were independent factors associated with stage 2-4 fibrosis in NAFLD patients.

Conclusions: Adiponectin and TNF-alpha gene polymorphisms were not shown to be associated with NAFLD or significant fibrosis in Chinese people. The adiponectin -11377G and +45G alleles were associated with hypertriglyceridemia in NAFLD patients. Since the current study is not adequately powered to detect smaller differences in allele frequencies, larger-sized studies in different ethnic groups are required.

MeSH terms

  • Adiponectin / blood
  • Adiponectin / genetics*
  • Adult
  • Asian Continental Ancestry Group*
  • Case-Control Studies
  • China / ethnology
  • Cohort Studies
  • Fatty Liver / diagnosis
  • Fatty Liver / ethnology*
  • Fatty Liver / genetics*
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polymorphism, Genetic*
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / genetics*

Substances

  • Adiponectin
  • Genetic Markers
  • Tumor Necrosis Factor-alpha