Post-prandial hypoglycemia after bariatric surgery: pharmacological treatment with verapamil and acarbose

Obes Surg. 2008 Dec;18(12):1618-21. doi: 10.1007/s11695-008-9569-9. Epub 2008 Jun 20.


Postprandial hypoglycemia is a common complication of bariatric surgery. It is usually caused by late dumping syndrome, but a few other causes have already been described, including insulinoma and noninsulinoma pancreatogenous hypoglycemic syndrome (NIPHS). Considering that NIPHS is a recently described syndrome and is also very rare, therapeutic approaches are still not consensual. We report the case of a 26-year-old woman who was submitted to bariatric surgery and presented episodic postprandial hypoglycemic episodes after 16 months. Fasting C-peptide, insulin, and glucose were normal. Because of the possibility of NIPHS, clinical treatment was initiated with verapamil and acarbose, leading to a significant reduction of hypoglycemic episodes and also their severity. Surgery is the most common approach to NIPHS. However, in cases of mild or moderate symptoms, it is important to consider the possibility of pharmacological treatment. This approach may result, at least for some time, in an amelioration of symptoms without the need of an aggressive procedure.

Publication types

  • Case Reports

MeSH terms

  • Acarbose / administration & dosage*
  • Calcium Channel Blockers / administration & dosage*
  • Drug Therapy, Combination
  • Dumping Syndrome / complications
  • Dumping Syndrome / drug therapy*
  • Dumping Syndrome / etiology
  • Dumping Syndrome / physiopathology
  • Female
  • Gastric Bypass / adverse effects*
  • Humans
  • Hypoglycemia / etiology*
  • Postoperative Complications / drug therapy*
  • Verapamil / administration & dosage*
  • Young Adult


  • Calcium Channel Blockers
  • Verapamil
  • Acarbose