Ras oncogenes: split personalities

Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31. doi: 10.1038/nrm2438.


Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to numerous insights that have revealed the involvement of Ras not only in tumorigenesis but also in many developmental disorders. Despite great strides in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins / metabolism
  • Enzyme Activation
  • GTPase-Activating Proteins / metabolism
  • Gene Expression Regulation
  • Genes, ras*
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phylogeny
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Sequence Alignment
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism
  • ras Proteins / chemistry
  • ras Proteins / classification
  • ras Proteins / genetics
  • ras Proteins / metabolism*


  • DNA-Binding Proteins
  • GTPase-Activating Proteins
  • SLC2A4RG protein, human
  • Transcription Factors
  • Phosphatidylinositol 3-Kinases
  • Mitogen-Activated Protein Kinases
  • ras Proteins