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Clinical Trial
, 18 (3), 447-51

Clinical Usefulness of Amitriptyline in Fibromyalgia: The Results of 23 N-of-1 Randomized Controlled Trials

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  • PMID: 1856813
Clinical Trial

Clinical Usefulness of Amitriptyline in Fibromyalgia: The Results of 23 N-of-1 Randomized Controlled Trials

R Jaeschke et al. J Rheumatol.

Abstract

Twenty-three double blind, randomized, multiple crossover trials (N-of-1 RCT) of amitriptyline were conducted in patients with fibromyalgia. The benefit of amitriptyline was assessed using a symptom questionnaire and count of tender points. To assess the usefulness of the method, the proportion of trials that provided a definite answer was examined. Completing the trial resulted in reaching a high degree of confidence in the final management decision in 74% of trials. In 35% of trials, results led to discontinuation of the drug which otherwise would have been continued indefinitely. The drug benefit, if present, was evident within first 2 weeks of therapy. We concluded that these results support the feasibility and usefulness of N-of-1 RCT in rheumatology practice.

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