Behavioral Symptoms After Pallido-Nigral Lesions: A Clinico-Pathological Case

Neurocase. 2008;14(2):125-30. doi: 10.1080/13554790802032200.

Abstract

A 59-year-old patient presented with compulsive behaviors and lasting apathy after carbon monoxide intoxication. The apathy could be overcome by external stimulation (self-activation deficit). There was severe neuronal loss bilaterally in the anterior part of the pallidum and in the substantia nigra, pars reticulata. This first clinico-pathological case of a self-activation deficit illustrates the dissociation between motor and behavioral symptoms in lesions of the pallido-nigral complex, with the behavioral symptoms being related to lesions of the substantia nigra, pars reticulata and of the anterior part of the pallidum.

Publication types

  • Case Reports

MeSH terms

  • Affective Symptoms / drug therapy
  • Affective Symptoms / etiology*
  • Art
  • Atrophy
  • Brain / pathology
  • Calcinosis / complications
  • Calcinosis / diagnostic imaging
  • Carbon Monoxide Poisoning / complications
  • Carbon Monoxide Poisoning / diagnosis
  • Carbon Monoxide Poisoning / pathology*
  • Carbon Monoxide Poisoning / psychology*
  • Chronic Disease
  • Compulsive Behavior / etiology*
  • Compulsive Behavior / psychology
  • Dopamine / therapeutic use
  • Globus Pallidus / diagnostic imaging
  • Globus Pallidus / metabolism
  • Globus Pallidus / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Substantia Nigra / pathology*
  • Tomography, X-Ray Computed

Substances

  • Dopamine