Mondia whitei has been used since ancient times as an aphrodisiac even though little scientific evidence exists about its efficacy. An aqueous extract of Mondia whitei was administered to human spermatozoa in vitro and motility parameters assessed. Mondia whitei significantly enhanced total motility as well as progressive motility in a time-dependent manner. These data may open the way for the use of Mondia whitei especially in men affected with asthenozoospermia.