Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman's syndrome)

Fertil Steril. 2008 Aug;90(2):409-14. doi: 10.1016/j.fertnstert.2007.06.034. Epub 2008 Jun 20.

Abstract

Objective: To evaluate postoperative blunt adhesiolysis after sharp adhesiolysis for the treatment of intrauterine adhesions.

Design: Retrospective analysis of 24 patients treated with primary hysteroscopic adhesiolysis followed by hormone therapy and serial flexible office hysteroscopy (Canadian Task Force Classification II-3).

Setting: University-affiliated community hospital.

Patient(s): Twenty-four women with menstrual disorders, pain, or infertility resulting from intrauterine adhesions.

Intervention(s): Serial, postoperative, hysteroscopic blunt adhesiolysis of recurrent synechiae.

Main outcome measure(s): Restoration of normal menstrual pattern, relief of dysmenorrhea, improvement in fertility, and improvement in stage of disease.

Result(s): Eighty-three percent of patients (20/24) presented with amenorrhea or oligomenorrhea, 67% (16/24) had either infertility or recurrent miscarriages, and 54% (13/24) presented with dysmenorrhea. Initially, 50% (12/24) had severe adhesions, 46% (11/24) moderate, and 4% (1/24) minimal disease according to the March criteria. Improvement in menstrual flow occurred in 95% (18/19) of patients, relief of dysmenorrhea occurred in 92% (12/13), and 46% (7/15) of fertility patients were actively pregnant or had delivered viable infants at the conclusion of the study. There was a 92% (22/24) improvement in disease staging over the treatment interval.

Conclusion(s): Blunt adhesiolysis with a flexible hysteroscope is effective for maintenance of cavity patency after primary treatment of intrauterine adhesions.

MeSH terms

  • Adult
  • Estrogens, Conjugated (USP) / therapeutic use
  • Female
  • Gynatresia / surgery
  • Gynatresia / therapy*
  • Humans
  • Hysteroscopy / methods
  • Middle Aged
  • Postoperative Care / methods
  • Retrospective Studies
  • Tissue Adhesions / surgery
  • Tissue Adhesions / therapy*

Substances

  • Estrogens, Conjugated (USP)