Acquired aquagenic papulotranslucent acrokeratoderma: report of two cases

Am J Clin Dermatol. 2008;9(4):263-5. doi: 10.2165/00128071-200809040-00006.


Aquagenic papulotranslucent acrokeratoderma (APA) is an acquired, unusual condition characterized by bilateral, symmetric, translucent-to-white papules located on the hands and feet. These lesions are accentuated following a short period of water exposure. Since its first description in 1973 as hereditary papulotranslucent acrokeratoderma, only a few cases of APA have been reported. We report two cases of teenage girls with APA. Both patients responded well to 5% salicylic acid ointment but recurrence of lesions still occurred. The close temporal proximity of presentation of these two cases may indicate that APA is not as rare as previously thought.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adolescent
  • Diagnosis, Differential
  • Female
  • Humans
  • Keratoderma, Palmoplantar / diagnosis*
  • Keratoderma, Palmoplantar / drug therapy
  • Keratoderma, Palmoplantar / etiology*
  • Recurrence
  • Salicylic Acid / administration & dosage
  • Water*


  • Water
  • Salicylic Acid