Interaction of Bride of Sevenless Membrane-Bound Ligand and the Sevenless Tyrosine-Kinase Receptor

Nature. 1991 Jul 18;352(6332):207-12. doi: 10.1038/352207a0.

Abstract

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Aggregation
  • DNA / genetics
  • Drosophila / genetics
  • Drosophila / physiology*
  • Drosophila Proteins*
  • Eye Proteins / genetics
  • Eye Proteins / physiology*
  • Ligands
  • Membrane Glycoproteins*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mosaicism
  • Mutation
  • Neurons / cytology
  • Neurons / physiology*
  • Photoreceptor Cells / cytology
  • Photoreceptor Cells / physiology*
  • Protein-Tyrosine Kinases / physiology*
  • Receptor Protein-Tyrosine Kinases*

Substances

  • Drosophila Proteins
  • Eye Proteins
  • Ligands
  • Membrane Glycoproteins
  • Membrane Proteins
  • DNA
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • sev protein, Drosophila