Abstract
During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Aggregation
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DNA / genetics
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Drosophila / genetics
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Drosophila / physiology*
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Drosophila Proteins*
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Eye Proteins / genetics
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Eye Proteins / physiology*
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Ligands
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Membrane Glycoproteins*
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Membrane Proteins / genetics
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Membrane Proteins / physiology*
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Mosaicism
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Mutation
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Neurons / cytology
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Neurons / physiology*
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Photoreceptor Cells / cytology
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Photoreceptor Cells / physiology*
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Protein-Tyrosine Kinases / physiology*
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Receptor Protein-Tyrosine Kinases*
Substances
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Drosophila Proteins
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Eye Proteins
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Ligands
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Membrane Glycoproteins
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Membrane Proteins
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DNA
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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sev protein, Drosophila