Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 352 (6332), 255-7

Paternal Inheritance of Mitochondrial DNA in Mice

Affiliations
Comparative Study

Paternal Inheritance of Mitochondrial DNA in Mice

U Gyllensten et al. Nature.

Abstract

For nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals. Using the polymerase chain reaction, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10(-4), relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished easily. This new mode of inheritance provides a mechanism for generating heteroplasmy and may explain mitochondrial disorders exhibiting biparental transmission.

Comment in

Similar articles

See all similar articles

Cited by 123 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback