Living on a break: cellular senescence as a DNA-damage response

Nat Rev Cancer. 2008 Jul;8(7):512-22. doi: 10.1038/nrc2440.


Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cellular Senescence / genetics*
  • DNA Damage*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology