The environmental contribution to gene expression profiles

Nat Rev Genet. 2008 Aug;9(8):575-81. doi: 10.1038/nrg2383.


Microarray analysis provides a bridge between the molecular genetic analysis of model organisms in laboratory settings and studies of physiology, development, and adaptation in the wild. By sampling species across a range of environments, it is possible to gain a broad picture of the genomic response to environmental perturbation. Incorporating estimates of genetic relationships into study designs will facilitate genomic analysis of environmental plasticity by aiding the identification of major regulatory loci in natural populations.

Publication types

  • Review

MeSH terms

  • Adaptation, Biological / genetics
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cluster Analysis
  • Environment*
  • Gene Expression Profiling*
  • Genetic Variation / physiology
  • Genomics
  • Humans
  • Models, Biological
  • Oligonucleotide Array Sequence Analysis
  • Pedigree
  • Transcription, Genetic / physiology