Review
doi: 10.1038/cr.2008.74.
Actions of human telomerase beyond telomeres
Affiliations
- PMID: 18574498
- DOI: 10.1038/cr.2008.74
Item in Clipboard
Review
Actions of human telomerase beyond telomeres
Cell Res.
2008 Jul.
Abstract
Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.
Similar articles
-
Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging.Exp Cell Res. 2004 Aug 15;298(2):445-54. doi: 10.1016/j.yexcr.2004.04.032. Exp Cell Res. 2004. PMID: 15265692
-
Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms.J Pathol. 2009 Feb;217(3):327-44. doi: 10.1002/path.2500. J Pathol. 2009. PMID: 19142887 Review.
-
Telomeres and aging.Physiol Rev. 2008 Apr;88(2):557-79. doi: 10.1152/physrev.00026.2007. Physiol Rev. 2008. PMID: 18391173 Review.
-
Resistance to apoptosis in human cells conferred by telomerase function and telomere stability.Mol Carcinog. 1999 Aug;25(4):241-8. Mol Carcinog. 1999. PMID: 10449030
-
Telomere dysfunction in aging and cancer.Int J Biochem Cell Biol. 2005 May;37(5):1000-13. doi: 10.1016/j.biocel.2004.09.003. Int J Biochem Cell Biol. 2005. PMID: 15743674 Review.
Cited by
-
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.Nat Cell Biol. 2024 Jun;26(6):932-945. doi: 10.1038/s41556-024-01427-6. Epub 2024 May 28. Nat Cell Biol. 2024. PMID: 38806647
-
TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT.iScience. 2024 May 3;27(6):109869. doi: 10.1016/j.isci.2024.109869. eCollection 2024 Jun 21. iScience. 2024. PMID: 38799568 Free PMC article.
-
Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes.Nat Commun. 2023 Sep 22;14(1):5912. doi: 10.1038/s41467-023-41472-7. Nat Commun. 2023. PMID: 37737237 Free PMC article.
-
The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.Oncogene. 2023 Mar;42(14):1144-1156. doi: 10.1038/s41388-023-02630-9. Epub 2023 Feb 23. Oncogene. 2023. PMID: 36823376 Free PMC article.
-
hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells.Cells. 2021 Apr 10;10(4):867. doi: 10.3390/cells10040867. Cells. 2021. PMID: 33920284 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
