Effect of atorvastatin on bone mineral density in patients with acute coronary syndrome

Eur Rev Med Pharmacol Sci. Mar-Apr 2008;12(2):83-8.

Abstract

Objective: The aim of this paper is to evaluate the effect of atorvastatin on bone mineral density in patients with acute ischemic heart disease.

Material and methods: Eighty-three patients (52 male and 31 female) with acute coronary syndrome were studied. They received treatment with atorvastatin using low doses (20 mg) and high doses (40 mg-80 mg). Initial and final cholesterol, triglyceride, calcium, phosphorus, 25-hydroxyvitamin D were obtained from every patient. Spine and hip bone mineral density were performed at the beginning and one year later.

Results: Atorvastatin treatment increases vitamin D (33%, p = 0.007) and decreases the individuals with vitamin D insufficiency. Bone mineral density increased in the spine (1.31%, p = 0.02), but it was significant only in male and patients presenting vitamin D levels higher than 30 nmol/l.

Conclusion: Atorvastatin has a beneficial effect on bone metabolism in patients with acute ischemic heart disease (mainly males) by incrementing bone mineral density in which vitamin D levels are required to be higher than 30 nmol/l for the drug to be effective.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Coronary Syndrome / drug therapy*
  • Aged
  • Atorvastatin
  • Bone Density / drug effects*
  • Female
  • Femur Neck / drug effects
  • Femur Neck / metabolism
  • Follow-Up Studies
  • Heptanoic Acids / pharmacology*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyrroles / pharmacology*
  • Risk Factors
  • Sex Factors
  • Spine / drug effects
  • Spine / metabolism
  • Vitamin D / blood
  • Vitamin D Deficiency / prevention & control

Substances

  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Vitamin D
  • Atorvastatin