6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34. doi: 10.1016/j.bbrc.2008.06.046. Epub 2008 Jun 23.

Abstract

In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation, and (2) 6G is not a PPARgamma agonist, but it is an effective inhibitor of TNF-alpha induced c-Jun-NH(2)-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects*
  • Adipocytes / metabolism
  • Adiponectin / biosynthesis*
  • Animals
  • Catechols / pharmacology*
  • Down-Regulation / drug effects
  • Fatty Alcohols / pharmacology*
  • Gene Expression / drug effects
  • JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Mice
  • PPAR gamma / agonists
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / pharmacology
  • Zingiber officinale / chemistry

Substances

  • Adiponectin
  • Catechols
  • Fatty Alcohols
  • PPAR gamma
  • Tumor Necrosis Factor-alpha
  • shogaol
  • gingerol
  • JNK Mitogen-Activated Protein Kinases