Quantification of regional myocardial blood flow using first-pass multidetector-row computed tomography and adenosine triphosphate in coronary artery disease

Circ J. 2008 Jul;72(7):1086-91. doi: 10.1253/circj.72.1086.


Background: The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment of myocardial blood flow (MBF) using the adenosine triphosphate (ATP) load technique was investigated in the present study.

Methods and results: The study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean age 69.2 years) who underwent cardiac cine MDCT using the ATP-load technique. MBF was estimated from the slope of the linear regression equation with Patlak plots analysis. The overall average MBF was 1.83+/-0.62 ml . g(-1) . min(-1). Mean MBF in territories with stenosis on coronary angiography was 1.19+/-0.36 ml . g(-1) . min(-1) and 2.06+/-0.54 ml . g(-1) . min(-1) (p<0.01) in territories without stenosis. The average MBF in territories with moderate to severe ischemia on myocardial perfusion scintigraphy was 1.32+/-0.14 ml .g(-1 ). min(-1 )and 1.95+/-0.64 ml . g(-1) . min(-1) (p<0.01) in territories without ischemia.

Conclusion: MDCT can be used to quantify MBF using first-pass dynamic data.

Publication types

  • Clinical Trial

MeSH terms

  • Adenosine Triphosphate*
  • Aged
  • Coronary Angiography / methods*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Circulation*
  • Exercise Test
  • Feasibility Studies
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Myocardial Ischemia / diagnostic imaging
  • Thallium Radioisotopes
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed / methods*


  • Thallium Radioisotopes
  • Adenosine Triphosphate