Treating sensitive cervical areas with ozone. A prospective controlled clinical trial

Am J Dent. 2008 Apr;21(2):74-6.


Purpose: To determine whether the treatment of hypersensitive teeth with gaseous ozone (Healozone, KaVo 1600 ppm) for 60 seconds reduces pain immediately after treatment and in the longer term.

Methods: In three private practices in Switzerland, 31 subjects suffering from hypersensitive teeth were treated with gaseous ozone over a period of 54 weeks (one test and one control tooth in each subject). A cross-over design was chosen. The pain level was measured with a Visual Analogue Scale before and after the treatment.

Results: The subjects' pain level was reduced by 55% +/- 5.5% immediately after the ozone treatment. Over time, the pain level decreased significantly in all groups: The pain level in the test teeth was significantly reduced in Weeks 0-22 (treatment group, P < 0.001) compared to the pain level before treatment. The pain level in the control group was also reduced significantly over time in Weeks 0-22 (no-treatment, P = 0.025) and in Weeks 22-54 (treatment group, P = 0.0065). Comparing test and control teeth over time, there was no statistically significant difference in pain reduction (P = 0.58).

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Cross-Over Studies
  • Dentin Sensitivity / drug therapy*
  • Female
  • Follow-Up Studies
  • Gingival Recession / classification
  • Humans
  • Male
  • Middle Aged
  • Oxidants, Photochemical / administration & dosage
  • Oxidants, Photochemical / therapeutic use*
  • Ozone / administration & dosage
  • Ozone / therapeutic use*
  • Pain Measurement
  • Periodontal Pocket / classification
  • Smoking
  • Toothpastes / therapeutic use


  • Oxidants, Photochemical
  • Toothpastes
  • Ozone