Immunoglobulin A pemphigus associated with immunoglobulin A gammopathy and lung cancer

J Dermatol. 2008 Jun;35(6):341-5. doi: 10.1111/j.1346-8138.2008.00481.x.

Abstract

Immunoglobulin (Ig)A pemphigus is a rare disease marked by a vesiculopustular eruption characterized by intercellular IgA deposition in the epidermis. It has clinical and histopathological heterogeneity and encompasses two subgroups: subcorneal pustular dermatosis type and intraepidermal neutrophilic IgA dermatosis type. IgA pemphigus has been rarely associated with monoclonal IgA paraprotein, myeloma and B-cell lymphoma in the past. We report the first case, to our knowledge, of a 47-year-old male patient with a subcorneal pustular dermatosis type of IgA pemphigus associated with IgA gammopathy and lung cancer.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / analysis
  • Fatal Outcome
  • Fluorescent Antibody Technique, Direct
  • Humans
  • Immunoglobulin A / analysis*
  • Lung / diagnostic imaging
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnostic imaging
  • Male
  • Middle Aged
  • Neoplasms, Squamous Cell / complications*
  • Neoplasms, Squamous Cell / diagnostic imaging
  • Paraproteinemias / complications*
  • Paraproteinemias / immunology
  • Pemphigus / complications*
  • Pemphigus / immunology
  • Pemphigus / pathology
  • Skin / pathology
  • Tomography, X-Ray Computed

Substances

  • Autoantibodies
  • Immunoglobulin A