Phagocytic signaling: you can touch, but you can't eat

Curr Biol. 2008 Jun 24;18(12):R521-4. doi: 10.1016/j.cub.2008.04.058.

Abstract

The ability of phagocytes to discriminate between viable/healthy and apoptotic/foreign/abnormal cells is of fundamental importance; a recent study provides new molecular insights into the function of CD47-SIRP alpha signaling in this discrimination.

MeSH terms

  • Animals
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / metabolism*
  • CD47 Antigen / genetics
  • CD47 Antigen / metabolism*
  • Erythrocytes / immunology
  • Gene Expression Regulation
  • Humans
  • Mice
  • Monocytes / physiology
  • Phagocytes / metabolism
  • Phagocytes / physiology*
  • Phagocytosis*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism*
  • Signal Transduction*

Substances

  • Antigens, Differentiation
  • CD47 Antigen
  • CD47 protein, human
  • Receptors, Immunologic
  • SIRPA protein, human