Symptomatic nephrolithiasis in prolonged survivors of Duchenne muscular dystrophy

Neuromuscul Disord. 2008 Jul;18(7):561-4. doi: 10.1016/j.nmd.2008.05.001. Epub 2008 Jun 24.


In this study, we describe the association between Duchenne muscular dystrophy (DMD) and symptomatic nephrolithiasis. The DMD patients were matched to non-ambulatory control patients with non-DMD neurological diagnoses via retrospective chart review. All patients with DMD and symptomatic nephrolithiasis were over 20 years old. We found that six of the 29 at-risk DMD patients had nephrolithiasis (20.7%) while only one of the 68 control patients had nephrolithiasis (1.5%) (p<0.0001). Controlling for duration of immobilization with stratified analysis, the risk ratio for nephrolithiasis among DMD patients compared with controls was 9.94. Using rate-based estimates of renal stone development per 10,000 patient-years, the ratio of stone development among DMD patients compared with controls was 18.5. On logistic regression analysis, the corrected odds ratio for nephrolithiasis comparing DMD patients to controls was 14.26. We conclude that, in our study group, DMD was an independent risk factor for symptomatic nephrolithiasis.

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Muscular Dystrophy, Duchenne / complications*
  • Nephrolithiasis / complications*
  • Odds Ratio
  • Retrospective Studies