"To B or Not to B?" B-cells and Graft Rejection

Transplantation. 2008 Jun 27;85(12):1705-14. doi: 10.1097/TP.0b013e318177793e.

Abstract

There is increasing evidence that various maturational stages of B-cells infiltrate various solid organ transplants undergoing acute rejection. The presence of immature CD20 and mature CD138 plasma cells associate with more aggressive and steroid-recalcitrant graft rejection and portend poor graft outcomes. Though associative, the causal role of B-cells in graft rejection remains to be better understood. This review discusses the possible roles of B-cells in graft rejection, whether involved as antigen presenting, as indirect effector, or antibody producing cells.

Publication types

  • Editorial
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / physiology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / physiology*
  • Graft Rejection / immunology*
  • Graft Rejection / physiopathology
  • Humans
  • Transplantation Immunology