Panton-Valentine Leukocidin associated with community acquired methicillin resistant Staphylococcus aureus: a case report and review of interim guidelines

Anaesthesia. 2008 Jul;63(7):764-6. doi: 10.1111/j.1365-2044.2008.05482.x.


We report a case of community acquired methicillin resistant Staphylococcus aureus pneumonia. The causative organism was positive for the toxin Panton-Valentine Leukocidin. This resulted in a severe pneumonia requiring a prolonged stay on our intensive care unit. This infection is becoming more common in the United Kingdom. It can cause a far more aggressive illness than the hospital acquired infection with a high mortality if it becomes an invasive infection. The Department of Health has recently produced interim guidelines for its treatment which we have also reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Bacterial Toxins / analysis*
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / therapy
  • Exotoxins / analysis*
  • Female
  • Humans
  • Leukocidins / analysis*
  • Methicillin Resistance*
  • Middle Aged
  • Pneumonia, Bacterial / microbiology*
  • Pneumonia, Bacterial / therapy
  • Pneumonia, Bacterial / transmission
  • Practice Guidelines as Topic
  • Prognosis
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / therapy
  • Staphylococcal Infections / transmission
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / isolation & purification
  • Staphylococcus aureus / metabolism*


  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin