Association between burnout and circulating levels of pro- and anti-inflammatory cytokines in schoolteachers

J Psychosom Res. 2008 Jul;65(1):51-9. doi: 10.1016/j.jpsychores.2008.02.007. Epub 2008 May 22.


Objective: The burnout syndrome has been associated with an increased risk of cardiovascular disease. The physiological mechanisms potentially involved in this link are underexplored. Knowing that a chronic low-grade systemic inflammatory state contributes to atherosclerosis, we investigated circulating cytokine levels in relation to burnout symptoms.

Methods: We studied 167 schoolteachers (median, 48 years; range, 23-63 years; 67% women) who completed the Maslach Burnout Inventory with its three subscales emotional exhaustion (EE), lack of accomplishment (LA), and depersonalization (DP). Levels of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha and of the anti-inflammatory cytokines interleukin (IL)-4 and IL-10 were determined in fasting morning plasma samples. The TNF-alpha/IL-4 ratio and the TNF-alpha/IL-10 ratio were computed as two indices of increased inflammatory activity. Analyses were adjusted for demographic factors, medication, lifestyle factors (including sleep quality), metabolic factors, and symptoms of depression and anxiety.

Results: Higher levels of total burnout symptoms aggregating the EE, LA, and DP subscales independently predicted higher TNF-alpha levels (DeltaR(2)=.024, P=.046), lower IL-4 levels (DeltaR(2)=.021, P=.061), and a higher TNF-alpha/IL-4 ratio (DeltaR(2)=.040, P=.008). Higher levels of LA predicted decreased IL-4 levels (DeltaR(2)=.041, P=.008) and a higher TNF-alpha/IL-4 ratio (DeltaR(2)=.041, P=.007). The categorical dimensions of the various burnout scales (e.g., burnout yes vs. no) showed no independent relationship with any cytokine measure.

Conclusion: Burnout was associated with increased systemic inflammation along a continuum of symptom severity rather than categorically. Given that low-grade systemic inflammation promotes atherosclerosis, our findings may provide one explanation for the increased cardiovascular risk previously observed in burned-out individuals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Affective Symptoms / diagnosis
  • Affective Symptoms / immunology
  • Affective Symptoms / psychology
  • Anxiety Disorders / blood
  • Anxiety Disorders / immunology
  • Burnout, Professional / blood
  • Burnout, Professional / diagnosis
  • Burnout, Professional / immunology*
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / immunology
  • Cytokines / blood*
  • Cytokines / immunology
  • Depersonalization / diagnosis
  • Depersonalization / immunology
  • Depersonalization / psychology
  • Faculty / statistics & numerical data*
  • Female
  • Humans
  • Immunologic Factors / immunology
  • Inflammation / blood
  • Inflammation / diagnosis
  • Inflammation / immunology*
  • Interleukin-1 / blood
  • Interleukin-1 / immunology
  • Lipopolysaccharides / blood
  • Lipopolysaccharides / immunology
  • Male
  • Middle Aged
  • Personality Inventory / statistics & numerical data
  • Risk Factors
  • Severity of Illness Index
  • Stress, Psychological / diagnosis
  • Stress, Psychological / immunology
  • Stress, Psychological / psychology
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / immunology


  • Cytokines
  • Immunologic Factors
  • Interleukin-1
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha