Triamcinolone acetonide in silicone-filled eyes as adjunctive treatment for proliferative vitreoretinopathy: a randomized clinical trial

Ophthalmology. 2008 Nov;115(11):1938-43. doi: 10.1016/j.ophtha.2008.05.016. Epub 2008 Jun 26.


Objective: To evaluate the effect of adjunctive intraocular triamcinolone acetonide (TA) in silicone-filled eyes on outcomes of vitreoretinal surgery for proliferative vitreoretinopathy (PVR).

Design: Prospective, randomized, controlled clinical trial.

Participants: Seventy-five eyes with rhegmatogenous retinal detachment and PVR grade C (posterior, anterior, or both) undergoing vitrectomy combined with silicone oil tamponade were included. Of these, 38 eyes were assigned randomly to the adjunctive treatment, whereas 37 eyes served as controls.

Intervention: All eyes underwent pars plana vitrectomy, membrane peeling, and silicone oil exchange, with or without relaxing retinotomy or retinectomy. In the treatment group, 4 mg TA was injected into the silicone-filled vitreous cavity at the end of the procedure. Silicone oil was removed 3 months after surgery in eyes with attached retinas.

Main outcome measures: The primary outcome measure was retinal reattachment rate at 6 months. Secondary outcome measures included visual acuity, rate of recurrent PVR, reoperation rate, and rise of intraocular pressure.

Results: Retinal reattachment without any reoperation was achieved in 32 eyes (84.2%) and 29 eyes (78.4%) in the adjunctive treatment and control groups, respectively, at 6 months (P = 0.5). No statistically significant difference was observed between the 2 groups in terms of any of the secondary outcome measures (P>0.05).

Conclusions: The outcomes of vitreoretinal surgery for established PVR are not improved significantly by adjunctive TA injection in silicone-filled eyes.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Combined Modality Therapy
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Injections
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Prospective Studies
  • Retinal Detachment / surgery*
  • Silicone Oils / administration & dosage*
  • Triamcinolone Acetonide / administration & dosage*
  • Vitrectomy*
  • Vitreoretinopathy, Proliferative / drug therapy*
  • Vitreoretinopathy, Proliferative / surgery*
  • Vitreous Body


  • Immunosuppressive Agents
  • Silicone Oils
  • Triamcinolone Acetonide