Hedgehog nanopackages ready for dispatch

Cell. 2008 Jun 27;133(7):1139-41. doi: 10.1016/j.cell.2008.06.011.


Hedgehog proteins are intercellular long-range signaling molecules that spread within tissues and activate gene expression during development. Vyas et al. (2008) propose that Hedgehog forms nanometer-sized oligomers that localize in proteoglycan-rich clusters at the surface of cells expressing Hedgehog. This nanoscale organization and enrichment in clusters ensures that Hedgehog is able to spread and activate signaling over many cell diameters.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila / chemistry
  • Drosophila / embryology
  • Drosophila / metabolism*
  • Gene Expression Regulation, Developmental
  • Hedgehog Proteins / chemistry
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / metabolism*
  • Heparan Sulfate Proteoglycans / metabolism
  • Signal Transduction*


  • Hedgehog Proteins
  • Heparan Sulfate Proteoglycans