Protein phosphatase 2A regulatory subunits and cancer

Biochim Biophys Acta. 2009 Jan;1795(1):1-15. doi: 10.1016/j.bbcan.2008.05.005. Epub 2008 Jun 3.


The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates. Accumulating evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In particular we highlight PP2A function in the regulation of MAPK and Wnt signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Humans
  • MAP Kinase Signaling System / physiology
  • Models, Biological
  • Neoplasms / enzymology
  • Neoplasms / etiology*
  • Neoplasms / metabolism
  • Protein Phosphatase 2 / metabolism
  • Protein Phosphatase 2 / physiology*
  • Protein Subunits / metabolism
  • Protein Subunits / physiology
  • Signal Transduction / physiology
  • Wnt Proteins / metabolism
  • Wnt Proteins / physiology


  • Protein Subunits
  • Wnt Proteins
  • Protein Phosphatase 2