Therapeutic Applications of Pomegranate (Punica Granatum L.): A Review

Altern Med Rev. 2008 Jun;13(2):128-44.

Abstract

The pomegranate, Punica granatum L., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the Mediterranean region, as far north as the Himalayas, in Southeast Asia, and in California and Arizona in the United States. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The synergistic action of the pomegranate constituents appears to be superior to that of single constituents. In the past decade, numerous studies on the antioxidant, anticarcinogenic, and anti-inflammatory properties of pomegranate constituents have been published, focusing on treatment and prevention of cancer, cardiovascular disease, diabetes, dental conditions, erectile dysfunction, bacterial infections and antibiotic resistance, and ultraviolet radiation-induced skin damage. Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacokinetics
  • Antioxidants / therapeutic use
  • Ellagic Acid / pharmacokinetics
  • Ellagic Acid / therapeutic use
  • Female
  • Humans
  • Lythraceae / chemistry*
  • Male
  • Mice
  • Phytotherapy*
  • Plant Extracts / pharmacokinetics
  • Plant Extracts / therapeutic use*
  • Rats

Substances

  • Antioxidants
  • Plant Extracts
  • Ellagic Acid