Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins

Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. doi: 10.1128/AAC.00452-08. Epub 2008 Jun 30.


From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-HIV Agents* / chemical synthesis
  • Anti-HIV Agents* / chemistry
  • Anti-HIV Agents* / pharmacology
  • Antimicrobial Cationic Peptides / chemical synthesis
  • Antimicrobial Cationic Peptides / chemistry*
  • Antimicrobial Cationic Peptides / metabolism
  • Antimicrobial Cationic Peptides / pharmacology
  • Cathelicidins
  • Cattle
  • HIV Infections / virology
  • HIV-1 / drug effects*
  • Humans
  • Microbial Sensitivity Tests / methods
  • Structure-Activity Relationship


  • Anti-HIV Agents
  • Antimicrobial Cationic Peptides
  • Cathelicidins