Opposing Roles for Glypicans in Hedgehog Signalling

Nat Cell Biol. 2008 Jul;10(7):761-3. doi: 10.1038/ncb0708-761.

Abstract

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions.

MeSH terms

  • Animals
  • Body Patterning
  • Drosophila melanogaster / anatomy & histology
  • Drosophila melanogaster / embryology
  • Glypicans / chemistry
  • Glypicans / metabolism*
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / metabolism*
  • Mice
  • Signal Transduction / physiology*

Substances

  • Glypicans
  • Hedgehog Proteins