Infectious disease complications of combat-related injuries

Crit Care Med. 2008 Jul;36(7 Suppl):S358-64. doi: 10.1097/CCM.0b013e31817e2ffc.


Background: : Strategies currently used to prevent morbidity and mortality associated with combat-related injuries include better training of frontline medical personnel, improved personal protective equipment, and deployment of fast-forward surgical assets with state-of-the-art equipment. These strategies allow patients to survive near-catastrophic injuries, placing a greater emphasis on the medical infrastructure to mitigate short- and long-term complications associated with these injuries.

Discussion: : Wounds have certain characteristics that promote the development of infections: the presence of devitalized tissue, foreign bodies, clots, fluid collections, and contamination of wounds with bacteria from the casualty's skin, the environment, and the hospital. All of these factors culminate in placing the casualty at risk of developing an infection.

Summary: : This article reviews the lessons learned from combat-related wound infections throughout history and in the current conflicts in Iraq and Afghanistan. Many of the management strategies used to prevent infections of combat-related injuries are applicable to the management of civilian trauma, whether associated with small arms fire or related to natural disasters such as earthquakes or tornadoes.

Publication types

  • Review

MeSH terms

  • Afghanistan
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents, Local / therapeutic use
  • Bacterial Infections / epidemiology
  • Bacterial Infections / etiology
  • Bacterial Infections / therapy*
  • Critical Care / organization & administration
  • Debridement
  • Drug Resistance, Multiple, Bacterial
  • Forecasting
  • Health Services Needs and Demand
  • Humans
  • Infection Control / organization & administration*
  • Iraq
  • Iraq War, 2003-2011
  • Microbial Sensitivity Tests
  • Military Medicine / organization & administration*
  • Sepsis / epidemiology
  • Sepsis / etiology
  • Sepsis / therapy*
  • United States / epidemiology
  • Wound Infection / epidemiology
  • Wound Infection / etiology
  • Wound Infection / therapy*
  • Wounds and Injuries / complications*


  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local