Risk factors for microbial keratitis with contemporary contact lenses: a case-control study

Ophthalmology. 2008 Oct;115(10):1647-54, 1654.e1-3. doi: 10.1016/j.ophtha.2008.05.003. Epub 2008 Jul 2.


Objective: To assess the relative risks (RR) of microbial keratitis (MK) for contemporary contact lens (CL) types and wearing schedules.

Design: A 2-year prospective case-control study begun in December 2003.

Participants: Cases were 367 CL wearers attending Moorfields Eye Hospital with proven or presumed MK. Controls were 1069 hospital controls, who were CL wearers with a disorder unrelated to CL wear, and 639 population-based controls who were CL wearers randomly selected from the Moorfields catchment area. Hospital patients completed a self-administered questionnaire; population-based controls were interviewed by telephone.

Testing: Multivariate analysis was done both for all cases of MK, and for the moderate and severe MK subgroups alone.

Main outcome measures: The RR for developing MK, and vision loss, for all lens types compared with planned replacement soft lenses (the referent).

Results: Compared with planned replacement soft lenses (the referent), the RR of MK was significantly increased with daily disposable (DD) CLs (RR, 1.56x [95% confidence interval (CI), 1.1-2.1]; P = 0.009) and differed between different brands of DD lens, was reduced for rigid lenses (RR, 0.16x [95% CI, 0.06-0.4]; P<0.001), and no different for silicone hydrogel or other types of soft lens. Although the risk of MK was higher overall among DD lens users, the risk of vision loss was less than for planned replacement soft CL users (P = 0.05); no DD lens users lost vision to the level of >or=20/40. The RR for overnight wear, for any lens type, was 5.4 times higher (95% CI, 3.3-10.9; P<0.001). Comparison of the DD soft CL types with planned replacement soft lenses (the referent), showed significant differences between brands for the risk of MK.

Conclusions: The risk of MK has not been reduced in users of DD and silicone hydrogel CLs. However, vision loss is less likely to occur in DD than in reusable soft CL users. Different brands of CL may be associated with significantly different risks of keratitis; understanding these differences should lead to the development of safer soft lenses. These findings suggest that lens/ocular surface interactions may be more important in the development of corneal infection than oxygen levels and CL case contamination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bacteria / isolation & purification
  • Case-Control Studies
  • Contact Lens Solutions
  • Contact Lenses / adverse effects*
  • Contact Lenses / statistics & numerical data
  • Corneal Ulcer / epidemiology*
  • Corneal Ulcer / microbiology
  • Eye Infections, Bacterial / epidemiology*
  • Eye Infections, Bacterial / microbiology
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • United Kingdom / epidemiology
  • Visual Acuity


  • Contact Lens Solutions