What Makes Pathogens Pathogenic

Genome Biol. 2008;9(6):225. doi: 10.1186/gb-2008-9-6-225. Epub 2008 Jun 24.


Metazoans contain multiple complex microbial ecosystems in which the balance between host and microbe can be tipped from commensalism to pathogenicity. This transition is likely to depend both on the prevailing environmental conditions and on specific gene-gene interactions placed within the context of the entire ecosystem.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / classification
  • Bacteria / genetics
  • Bacteria / pathogenicity*
  • Host-Pathogen Interactions
  • Humans
  • Mutation
  • Virulence*