Pharmacodynamics of nicotine: implications for rational treatment of nicotine addiction

Br J Addict. 1991 May;86(5):495-9. doi: 10.1111/j.1360-0443.1991.tb01796.x.


Rational treatment of the pharmacologic aspects of tobacco addiction includes nicotine substitution therapy. Understanding the pharmacodynamics of nicotine and its role in the addiction process provides a basis for rational therapeutic intervention. Pharmacodynamic considerations are discussed in relation to the elements of smoking cessation therapy: setting objectives, selecting appropriate medication and dosing form, selecting the optimal doses and dosage regimens, assessing therapeutic outcome, and adjusting therapy to optimize benefits and minimize risks.

MeSH terms

  • Administration, Cutaneous
  • Arousal / drug effects
  • Arousal / physiology
  • Behavior Therapy / methods
  • Chewing Gum
  • Emotions / drug effects
  • Emotions / physiology
  • Humans
  • Nicotine / administration & dosage
  • Nicotine / pharmacokinetics*
  • Smoking / blood*
  • Smoking / psychology
  • Smoking / therapy
  • Substance Withdrawal Syndrome / blood
  • Substance Withdrawal Syndrome / prevention & control
  • Substance Withdrawal Syndrome / psychology


  • Chewing Gum
  • Nicotine