[Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study]

Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):711-5. doi: 10.3736/jcim20080710.
[Article in Chinese]

Abstract

Objective: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.

Methods: Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 microg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours.

Results: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 microg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 microg/ml curcumin after 6- and 24-hour culture (P<0.05).

Conclusion: 100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.

MeSH terms

  • Adiponectin / metabolism*
  • Adipose Tissue / metabolism*
  • Adult
  • Curcumin / pharmacology*
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-6 / metabolism*
  • Male
  • Middle Aged
  • Tissue Culture Techniques

Substances

  • Adiponectin
  • Interleukin-6
  • Curcumin