Emerging treatments for thrombocytopenia: increasing platelet production

Drug Discov Today. 2008 Sep;13(17-18):798-806. doi: 10.1016/j.drudis.2008.06.002. Epub 2008 Jul 17.

Abstract

Thrombocytopenia is a common medical problem. The first generation thrombopoietic agents, recombinant THPO and 'megakaryocyte growth and development factor' (PEG-rHuMGDF) entered clinical trials, but their development was discontinued owing to neutralizing auto-antibodies cross-reacting with endogenous THPO, causing thrombocytopenia in healthy volunteers. Although an approved drug for prevention of severe thrombocytopenia following myelosuppressive chemotherapy (human Interleukin-11) exists, the search for new thrombopoietic agents continued because its use is limited by side effects. Several second generation thrombopoietic factors have entered clinical trials and some new negative regulators of megakaryopoiesis have been found, such as platelet factor 4 (PF4) and the pituitary adenylate cyclase activating polypeptide (PACAP). Their inhibition may be useful in the treatment of thrombocytopenia. This article reviews second generation thrombopoietic factors and those recently discovered regulators of megakaryopoiesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / drug effects*
  • Blood Platelets / physiology
  • Cell Proliferation / drug effects
  • Humans
  • Megakaryocytes / drug effects
  • Platelet-Derived Growth Factor / therapeutic use
  • Thrombocytopenia / drug therapy*

Substances

  • Platelet-Derived Growth Factor